Test of nerve regeneration drug

Two antibodies that help regenerate ruptured spinal nerves of mice are about to be tested on humans.

These antibodies have helped the damaged ropes to travel. They block Nogo's activity - a protein that blocks nerve cells from developing new connections.

Images of human lifelong when autopsy (Photo: VNN) However, some people fear that Nogo blockade will not be able to control the regeneration of nerve cells in the brain or in the live wire. It is unclear how to use this therapy for people.

Martin Schawab and his colleagues at the University of Zurich (Switzerland) used a pump and catheter to bring two antibodies 11C7 and 7B12 into the cerebrospinal fluid surrounding the damaged living wire of the mouse.

The results showed that these antibodies reconstructed axons - thread-like bonds, connecting nerve cells and making mice swim, jump and walk.

In addition, antibodies do not cause hyperalgesia - a disease in which just a slight touch of the mouse is painful. The reason is due to the wrong connection between nerve cells.

In cooperation with Novartis, Schwab's group made antibodies suitable for humans. He said the group plans to conduct a clinical trial in the very near future, lasting 2-3 years.

"There is enough experimental evidence to be optimistic about these tests," said Robin Franklin, a neurologist at Cambridge University.

According to Lisa Schell, a member of the research team, Nogo alone cannot make the mouse recover completely. It may be a factor associated with other methods of treating the injury that live.

It is known that Geoffrey Raisman of the University of London is studying the stimulants needed to regenerate nerves. He did that by transplanting the cells from the back of the nose into the patient's live wire. These cells are known for their ability to stimulate the regeneration of damaged nerve fibers.

This method has shown promising results in paralyzed dogs. They move their legs after transplanting. Clinical trials are scheduled to begin this year.

Nick Jeffery, a veterinary surgeon at Cambridge, conducted such tests in dogs. He recommends not translating the results in animals into human results. Nogo blockade in humans may have unknown effects on the body.

Minh Son (According to NewScientist)