Anti-cancer drugs: Miracle test

Until this day, to deal with cancer, many measures have appeared. Basically, cancer treatment consists of four main measures: surgery, radiation, chemicals and immunity. Although there are serious side effects, we cannot deny the role of cancer chemotherapy in the process of reversing this incurable disease.

Cells 'destroy'

The first characteristic of cancer cells is the fast reproductive rate and strong survival ability . They reproduce continuously and have almost no time to rest. Not only that, they also have the ability to take nutrients from surrounding healthy cells and even take them all. If it is easy to visualize, these cells are called greedy ' thieves '. The more they feed, the more they get and the faster they grow So, the reproductive rate of cancer cells far exceeds that of normal cells. On the other hand, they have the ability to stimulate blood vessels to nourish themselves. Therefore, they can survive even if the body is seriously malnourished.

A cancer cell is dividing.

The second characteristic is the ability to escape the body's control. Healthy cells must be closely associated with other ' neighbors ' cells to survive. They link together to coexist with the structure of the organ. They always send - receive each other's control information. One cell cannot overgrow invasive cells and space of neighboring cells. These messages are always sent through the associated corpuscles, but the cytokine is secreted by the cell. But cancer cells have a special ability, they exist but do not need to bind to surrounding cells and get rid of body tissue control and censorship.

Third, cancer cells are capable of spreading throughout the body. If a normal cell is disconnected from the neighboring cells, immediately, they cannot exist because they lose their nourishment. But for cancer cells, this is not a big obstacle. They are able to separate themselves from the tissue and tend to separate themselves from the old population, floating in the blood and lymph, stopping themselves anywhere on their way. When stopped, they have the ability to adhere, securely attach to the tissue and recreate a new block like the original block despite being far away. This superhuman ability of cancer cells is called metastasis.

Where does medicine learn?

Only appeared for more than 3 decades but the cancer pharmaceutical industry has produced many products with effective treatment effects. Cancer treatment chemicals can be used as a single therapy or as a combination therapy to treat diseases. Either way, cancer pharmacology has its advantages that other measures are difficult to obtain.

From a clinical perspective, the cancer chemotherapy consists of four main groups. The first group is alkylating agents including substances that are able to transfer alkyl groups into biological molecules that impair the function of these molecules. Alkyl AND will lead to cell death and cancer cells will therefore be destroyed. The second group is metabolic drugs. These are chemical agents that alter the biosynthesis of genetic material (nuclotid and nucleic), thus seriously affecting the process of cell reproduction. The third group is plant allkaloid such as vinblastine, vincristine, bleomycin, dactinomycin, daunorubicin, doxorubicin, etoposide, idarubicin . These drugs are extracted from plants. The fourth group is hormonal substances to reduce hormone levels in the cancer. This group is used to kill tumors whose hormonal dependence such as breast cancer, testicular cancer, and ovarian cancer.

And the magic test

Fingolimod is used as an immunosuppressant.

At Centenary Research Institute, ovarian cancer cells were tested with cisplatin and a new promising drug, FTY720. FTY720 is still known as fingolimod, a synthetic derivative of sphingosine, which has long been used as an immunosuppressant to treat rejection, treat diseases such as multiple sclerosis and many diseases Other autoimmune. It is also used in the treatment of some types of cancer. And this time it was tested to understand the mechanism of resistance.

But a luck and a scientific success have appeared. Scientists have found that FTY720 not only has the ability to destroy normal ovarian cancer cells but also has the effect that all ovarian cancer cells are completely resistant to cancer chemicals , but Specifically in this experiment is resistant to cisplatine, making them unable to resist, repair or regenerate. The special thing is that people also discovered a new way to destroy cancer cells. Because common chemicals that kill cells all share the same mechanism, they start the programmed cell death cycle associated with the enzyme caspase, a protein that breaks down proteins. But FTY720 can start this process independently of caspase yeast, meaning that without these enzymes this process is still being performed. This is extremely significant as we not only provide treatment opportunities for treatment-resistant cancer patients but also open up a new field in cancer chemotherapy preparation according to a new method.

With experiments like this, we hope not too far to open the door to push the secret to permanently and completely destroy cancer cells, not only with ovarian cancer cells but also many types of cancer. another.