Identify genes that cause spina bifida

Researchers from McGill University (Canada) have identified the gene that causes live cracks, a birth defect caused by a defect in the fetal spinal cord formation. For every 1,000 births, there are 1 to 2 cases of this disability.

The research group led by Professor Philippe Gros identified three mutations of VANGL1 gene as a risk factor for malformations in the spinal canal of humans. They have studied spina bifida in mice for more than 10 years and are the first to make copies of this gene to perform laboratory research before conducting clinical trials in humans.

These results do not affect the preparation of the drug but may affect the diagnosis or assessment of the risk of disease.

Previous studies have demonstrated that supplementing folilic acid during pregnancy reduces 50 to 70% of the risk of having a baby with spina bifida.

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