Miscarriage due to hormone deficiency

Many women experience recurrent miscarriages due to lack of hormones in the body. For treatment, pregnant women need to take hormonal drugs and check with doctors regularly.

In normal women, after ovulation, the follicle remaining in the ovary will turn into a special endocrine gland called the corpus luteum (or corpus luteum). The corpus luteum will secrete progesterone ( also known as hormonal pregnancy ) and estrogen to facilitate nesting and development of pregnancy in the womb.

If the ovule is released during the menstrual cycle that is not fertilized (the woman is not pregnant), the corpus luteum will shrink at 25-26 days of the menstrual cycle and then 2-3 days later, the woman will again have a new period. In case of fertilized ovule, the embryo will nest in the uterus, developing there, the corpus luteum will be maintained and continue to develop to provide hormones needed for pregnancy; at that time it was called ' the corpus luteum '.

In order for the corpus luteum to survive, the embryonic cells of the embryo that have been rooted into the uterine lining will secrete a special hormone, HCG. This substance helps the corpus luteum to continue to develop the hormones necessary for pregnancy during the first 4 months of pregnancy. In the 5th month, the placenta itself has developed and become an endocrine gland that can provide enough of pregnancy hormones, the role of the corpus luteum is no longer needed, at this time the new fetal corpus luteum shrinks.

Thus, if in the early stages of pregnancy, the corpus luteum secretes inadequate hormones or atrophy too soon it can lead to miscarriage. To diagnose miscarriage due to lack of endocrine, it is necessary to do very complex quantitative hormone tests, which are difficult to perform in our country. If it is possible, the confidence level is also limited because each person and each pregnancy, the dose of hormone needed may vary. So, in fact, gynecologists give hormones to keep the pregnancy.

The most commonly used drug is progesteron - the fetal hormone of the corpus luteum, which is injected into the muscle, the dose, administration, and time will be decided by the gynecologist. This is the main drug to treat pregnancy. Injectable drugs can be replaced with oral tablet progesterone like duphaston, utrogestan.

The hormone of the corpus luteum is secreted not only in progesterone but also in estrogen, so in the treatment of threatened miscarriage or to keep the pregnancy, this substance is also added. The drug used in the past is diethylstinbestrol, which has the potential to cause vaginal cancer for the patient's daughter. Currently the drug used is usually ethinyl estradiol (brand name Mikrofollin). The dose and duration of use must be decided by a gynecologist after the examination.

Another hormone used in endocrine abortion is a type of pregnancy hormonal hormone, an active substance similar to HCG of placental vegetables secreted to maintain the corpus luteum with the name of Pregnyl.

Dr. Pho Duc Nhuan , Health & Life