Preparing new anti-cancer drugs with high effectiveness

In a recent clinical trial, a group of 24 scientists from the US, Europe, Taiwan, and Japan found a new generation of anticancer drugs that was 200 times more effective than drugs. Current anti-cancer.

Bisphosphonates activate gamma delta T - cells to kill cancer cells.

According to scientists, this new anti-cancer composition belongs to a drug line called Bisphosphanates. These compounds were originally studied for the treatment of osteoporosis and other diseases, but it has recently been shown to be effective in treating immune-related diseases and cancer.

Research results show that Bisphosphonates affect enzymes, called FPPS and GGPPS. These enzymes are responsible for the mutation in Ras gene (a protein). New anti-cancer drugs have inhibited the appearance of these enzymes, helping to effectively act to kill cancer cells.

When used in combination with hormone therapy in recent clinical trials, Bisphosphonate has significantly reduced the recurrence of breast cancer for premenopausal women. Similar results were previously reported for prostate cancer.

The team evaluated the new drug to be 200 times more effective than the drugs used in current clinical trials to kill tumors as well as in gamma delta T - cell activation. kill cancer cells.

Professor Eric Oldfield of the University of Illinois, who led the new study, said: "We try to develop Bisphospanates so that they are highly active without binding to bone tissue, because if bound to bone, it will not go to other tissues like breast, prostate and other tissues in the body ".

His colleagues are also trying to find a drug that stimulates many enzymes in the cell's path of survival, similar to the use of many kinase inhibitors in cancer treatment.