Take cholera vaccine

Vaccines described by the late Prof. GS Duc Dang Duc Trach are currently being produced by No.1 Vaccine and Biological Products Company (Vabiotech). Take 2 doses, effectively prevent disease for 3-5 years. Vabiotech is stockpiling more than 300,000 doses of vaccine in stock.

For cholera, without timely preventive measures often spread into large epidemics with very high mortality rates. As a precaution, the World Health Organization recommends the production of cholera vaccines that are inactivated all over the cell.

Cholera: Things to know

Cholera is an acute intestinal infection caused by cholera bacteria.The disease is easily spread, causing epidemics in various forms: sporadic epidemics, circulating fluids and pandemics.Patients with severe diarrhea and diarrhea symptoms;white feces like water in rice;possible vomiting, abdominal pain, mild fever.

In addition, there are signs of dehydration: wrinkled skin, sunken eyes, thirst.Easy disease spreads through water.Cholera bacteria persist in the water, even in seawater and in ice.The second pathway is food, especially fresh seafood such as shrimp, fish, oysters . Prevention: Needing hygiene and eating, eating cooked, boiling;sanitation of water sources and accommodation;take the vaccine to prevent cholera.

(According to documents of Vabiotech)

State-level research projects 69B-07-03-01 ' Research on production of cholera vaccine ' (1990-1991) and KY 01-03 ' applied scientific progress to improve technology Production of oral vaccines for cholera at semi-industrial scale '(1992-1994) by the late Professor. TSKH. Dang Duc Trach served as the chairman of the 2000 state award.

Try GS-TSKH Dang Duc Trach is a People's Doctor, Hero of Labor due to his great dedication to preventive medicine in Vietnam and he has spent a lot of time and enthusiasm for research on vaccines. Please this).

Since 1997, vaccines have been produced on an industrial scale, providing about 1 million doses per year for the Expanded Immunization Program.

This is a research project that works with Swedish scientists and has the same production technology with Swedish vaccines. The vaccine is given in 2 doses (1.5 ml each) at 2 weeks apart, the vaccine is safe, has few side effects. Field trials in Hue City have demonstrated the vaccine's efficacy of 66% after 8-10 months of vaccination (THE LANCET magazine, No.9047).

After taking the vaccine for 3-5 years, the protective effect is still 50% (VACCINE 24 (2000) 4297-4303). Be aware that with a special vaccine that is inactivated, the protective effect is good.

Research on vaccine production.(Photo: SK & D)

I would like to explain further, when saying that the protective effect of the vaccine is 66%, it does not only mean 66% of the protected patients do not get the disease but the rest of them are infected with the clinical disease. will be less serious. The reason is that the rate of people receiving an immune response is much higher (probably over 90%). More importantly, this number of people will be a barrier to prevent and reduce the source of disease transmission. Therefore, it will prevent or reduce the rate of epidemic spread.

Currently, this inactivated cholera vaccine is being produced at the No. 1 Vaccine and Biological Company and is stocking more than 300,000 doses of vaccine in stock.

Vaccine manufacturing factory in Vietnam invested by the Government has come into operation, including the production line of cholera vaccine with a capacity of 10 million doses / year, ensuring sufficient for the prevention of disease. of people in high-risk areas.

Vaccines are described in Vietnam and around the world

Dr. Dang Duc Anh (National Institute of Hygiene and Epidemiology) in an article on cholera vaccine published in the Health and Life newspaper gave more information about the vaccine produced by Vietnam as follows:

Cholera vaccine produced by Vietnam (Photo: Vabiotech)

Cholera is still happening every year in 50 countries.Research for a long time to have a cholera vaccine is still a top concern of world medicine.

In our country, the research work on cholera vaccine started in the late 80s, the research team led by the late Professor Dang Duc Trach and the National Institute of Hygiene and Epidemiology successfully developed the cholera vaccine. highly effective, can be produced on a large scale in the context of equipment available in us, at an affordable price that can be widely used in public health, sustainability High for easy storage and transport, and simple ways of getting into the body can cause immunity.Vaccines produced by fermentation technology, can produce 5-6 million doses per year, with the equipment available and cheap.Vaccines do not need to be stored in special cold conditions and their use is simply to drink.

Worldwide, there are two types of vaccines being used as Swedish and American vaccines.Both vaccines are high cost (US $ 15 and US $ 20), so they are not widely used in public health, but are only used in European and American countries for people who have money to travel through. areas at risk of cholera.Both vaccines need to be stored at a low temperature and when used must be accompanied by a buffer solution to neutralize the pH of the gastric juice, if it is not convenient to use when it is necessary to prevent the epidemic in a difficult situation.

Assoc. Doan Thi Thuy (Central Institute of Hygiene and Epidemiology)