The gene that causes IgAN kidney disease in humans has been discovered

The Singapore Science and Technology Research Institute announced on January 3 that a group of scientists from China and China have identified new genes that can cause IgAN kidney disease, a disease that now affects a large number of people. Asian number.

This discovery has helped scientists advance further insights into further studies of the treatment regimen for immunoglobulin A Nephropathy , IgAN . This is a form of chronic glomerulonephritis, first described by Berger and Hinglais in 1968, with anatomical-immunological characteristics that have IgA (a type of immune globulin ) deposited in the glomerular vascular spaces. .

This gene was discovered after a group of scientists led by the Director of Singapore's Gene Institute (GIS) Mr. Luu Kien Quan and Mr. Duc Tuyet Thanh of First Affiliated Hospital of Yat-Sen University, Guangdong , China conducted a large-scale gene study to detect IgAN in a large number of Chinese populations.

IgAN disease is very popular in Asia with the rate of infection is as high as 3.7%, while this rate in white people is only 1.3% and some other individual cases of African descent . According to statistics, this disease has made 15-40% of Asian patients fall into kidney failure and new kidney transplant must be conducted.

Mr. Liu said the finding was a breakthrough in research on IgAN disease.'It is interesting that we found that some gene variants can affect and show the clinical manifestations and infection of the disease ,' Liu said.