Detection of new active ingredients in the treatment of chronic chronic hepatitis B

Hepatitis B virus is one of the most common infectious diseases in the world and is one of the highly fatal diseases. It is estimated that more than two billion people worldwide are infected with hepatitis B virus (HBV) and about 350-400 million people are chronically infected with HBV.

About 25 to 40% of people with chronic HBV infection die prematurely because of cirrhosis and / or liver cancer. Vietnam is one of the countries with a high prevalence of hepatitis B, an estimated 10 million people with HBsAg, so hepatitis B is an important issue in public health.

This disease is the leading risk of liver failure, cirrhosis, liver cancer and death . Vaccination is now considered the most effective way to prevent this disease. However, for people who are already infected, especially active chronic hepatitis B, treatment becomes extremely difficult and expensive.

Prickly coffee.

According to the American Association of Liver Research Association (AASLD) guidelines published at the APASL 2007 conference in Asia, the primary goal of treatment is to achieve sustained inhibition of hepatitis virus replication. B and repel liver disease. The ultimate goal is to prevent cirrhosis, liver failure and liver cancer. For patients with chronic hepatitis B, the active system (about 25%) needs specific drug treatment. Some specific drugs are currently being used with hepatitis B: Interferon alfa, Peginterferon alfa, Lamivudine, Adefovir Dipivoxil, Emtricitabine (FTC), Tenofovir Disoproxil Fumarate, Entecavir . These drugs are often expensive, must be used prolonged to maintain viral suppression.

The current trend of interest in the scientific community is to search for new active ingredients derived from herbs that help treat this dangerous disease. In particular, Ca gai tree (Solanum hainanense Hance Solanaceae) is specially paid attention and studied carefully and is considered to be very promising in treatment. A lot of research topics on Ca Mau climbing plants have been done. Scientists have discovered the new active ingredient in Ca Mau coffee that inhibits replication and negative activity of hepatitis B virus. It is Glycoalcaloid.

National research project ' Drug research from Ca Mau climbing medicine as an anti-inflammatory drug and inhibiting the development of cirrhosis ' by TS. Chairman Nguyen Thi Minh Khai proved effective against hepatitis, inhibited the development of cirrhosis and anti-oxidation of the whole extract form and the main active form of glycoalcaloid on the experimental model of organisms. The drug is tested on voluntary patients, the drug does not have side effects, is allowed by the science council to conduct clinical research. In a phase 2 clinical trial, the results of treatment in patients with chronic active hepatitis B showed that the drug had a very positive effect, in the group of patients treated with drugs Ca gai leo, clinical symptoms. sieve decreased faster, enzyme GOT, GPT and bilirubin were normal faster (compared with control group); Especially, 23.3% of patients lost HBsAg and 44% of patients appeared anti-HBe. The results of phase 3 clinical research for 90 chronic hepatitis B patients operating at 3 institutions Military Hospital 103, Central Hospital 108, Vien Quan Y 354 all have very good and appropriate results. with the results obtained in phase 2, especially Military Hospital 354 found that HBsAg lost 16.6% (negative). In phase 3, further monitoring of HBV-DNA levels indicated that the drug was effective in inhibiting HBV replication after two months of treatment. Another special feature in stage 3 is Military Hospital 103, which further treats 7 patients for 6 months, resulting in 1 more patient losing HBsAg and appearing anti-HBs.

One thing in particular is that Ca gai Ca can work very well to solve alcohol . Before drinking alcohol, only need to root the roots of Ca gai tree, then it will take a long time to get drunk. Experimental soaking Ca gai with alcohol is only after one night a large amount of alcohol is destroyed (currently unknown cause).

The thesis also researches and completes the extraction process, processes to create a film-coated drug product that meets the standards of the Ministry of Health and testing institute for appraisal.

From the results of the above studies, it can be concluded that Caodifolia is used as a cure for hepatitis very well, especially active chronic hepatitis B. This is an important contribution of the research topic because chronic active hepatitis B has so far been a concern of many countries' health sectors. This also shows that our medicinal plants have a strong effect and will contribute significantly to the care and protection of people's health if given proper attention.