Means of controlling cell interaction

A new technology that helps control cellular interactions at the nanoscale has achieved unprecedented results.

Using nanotechnology to design cell surface sensors, researchers at Brigham and Woman's Hospital (BWH) have developed a fundamental technique to control single cell interactions in time. real-time. This invention meets the research needs of both science and medicine by providing a deeper understanding of complex cell biology processes, controlling transgenic cells, and developing methods. Effective therapy. This research was published in Nature Nanotechnology .

' Now we can control how cells communicate with each other in real time using the space-time analysis method that has not been available before ,' Gs. Jeffrey Karp said. ' This allows us to understand how to transfer signals between cells and to interact with drugs at high levels of detail, and will provide a basis for basic research and drug development . '

Cell signal sensors used by researchers now have difficulty measuring the activity in a dense group of cells. In this study, researchers at BWH used nanotechnology to attach a sensor to a single cell membrane, allowing them to control the signals entering the nano environment inside the cell. These cells are directly attached to the widely used sensors in cells and implants.

' When using this tool to study drug interactions with cells about basic conditions, it has the potential to be a drug for every patient in the future. One day we could test the effect of the drug on cell-cell interactions before deciding on the right treatment for each person, ' Gs. Wean Zhao said.

Scientists are very excited to have the basic data showing the potential to use this innovative method to monitor and control the surrounding environment of transgenic cells, which was not possible before. . This achievement is useful to formulate a deeper understanding of signaling during the treatment of many diseases.

' This new study is an important step towards achieving real-time observation goals with the possibility of' wide-area analysis - high spatial resolution 'on inter-cell communication, with progressive orientations. Further in the development of new therapeutic drugs and diagnostic methods, ' Gs. Ulrich von Andrian said.