Sperm selection device: new hope in treating infertility

Researchers have developed a new device that can select the best sperm in millions of sperms in just 30 minutes for use in assisted reproductive technologies such as in vitro fertilization. The device is based on microfluidic technology, which reduces the risk of DNA damage associated with conventional sperm classification and can help infertile couples get healthy babies.

Around the world, nearly 48.5 million couples cannot give birth after trying 5 years or even longer. Although in vitro fertilization, uterine sperm pumping and oocyte sperm injection are effective treatment options for infertile couples, but only about a third of the cases use methods. This results in children living.

Male infertility accounts for about 30-50% of all infertility cases.

Male infertility accounts for about 30-50% of all cases of infertility and infertile men often have abnormal sperm characteristics such as low sperm density, poor sperm movement, irregular shape and size and High level of DNA damage. DNA damage is one of the more important traits of sperm because higher levels of injury are associated with lower pregnancy rates, early miscarriages and child morbidity of couples using assistive technology. higher reproductive support. That is why it is necessary to develop the most healthy sperm selection methods for assisted reproductive technology.

The most commonly used or convenient method for assisted reproductive technology involves a technique called centrifugation . Although this method is effective in selecting normal sperm in terms of mobility and morphology, this procedure is difficult to understand because it often increases the concentration of chemicals that cause DNA damage.

Asghar's device includes an input to inject an untreated semen sample and two plastic chambers separated by a porous membrane. The most healthy and mobile sperms swim through the porous membrane leaving less active and dead sperm in the lower chamber. Using this selection technology, a technician just injects semen samples into the device and can then choose healthy sperm in the upper chamber for about 30 minutes, making sperm selection easy. easier. Compared to other techniques used for assisted reproductive technology, the use of this microfluidic device results in a significant reduction in the rate of DNA damage and improved sperm recovery using methods. this.