Successful study of drugs for autism in experimental mice

( autism ) - Autism is caused by abnormal communication between cells. Examining a new assumption, researchers at the University of California, San Diego Medical School used a newly discovered function of an old drug to restore communication cells in a sample mouse that was Autism, which helps to reduce signs of dangerous mental disorders.

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This discovery was published in PLOS ONE magazine on March 13, 2013.

'Our hypothesis about cell danger suggests that the cause of autism is that cells are trapped in a closed metabolic regime, and cannot communicate with each other in a way. normally, this may affect brain development and function , " said Robert Naviaux, medical doctor, assistant doctor, medical professor and co-director of the Center for Mitochondrial Diseases and "In order to prevent the dangerous signs of lab rats, allow rotary cells to regain normal metabolic processes and restore cellular communication," said the University of California, San Diego. We use a drug that has been used for almost a century to treat various diseases ".

"Of course, adjusting the abnormalities in a mouse is very different from treating people , " Naviaux said. However, this result encourages us to test this method in the future, in a small clinical trial facility for children with autism spectrum disorders by age. This test work is still in the early stages. We think this approach - known as APT anti-purpine therapy - opens up a new and exciting path that drives the development of a new drug to treat autism. "

Successful study of autism medications

Age- related autism disorders (ASDs ) are complex disorders manifested by abnormalities in the development of language, social behavior, and repetitive behavioral behaviors. Hundreds of different genetic and environmental factors are known as factors that contribute to the risk of autism. In this study, nearly a dozen UC San Diego scientists in various disciplines collaborated to find a unified mechanism for autism. Their work has achieved remarkable achievements as one of three international awards' Trailblazer'do for Austism Speaks group awarded in 2011.

Describe a completely new theory of the origin and treatment of autism using APT therapy, Naviaux and colleagues published a new knowledge that, essentially, both weak Genetic factors and habitats all cause autism by, creating a dangerous cellular reaction - the metabolic state containing innate immunity and agitation.

When cells are exposed to traditional forms of danger, such as infections, viruses or toxic environmental substances, a protection mechanism is activated, Naviaux explains."This leads to changes in gene expression and metabolism, and reduces communication between neighboring cells. Simply put, when cells stop talking to each other, children stop talking".

Because mitochondria - known as the cell's "energy plant" - play a central role for both cell types that can infect other cells and non-infectious cells, immunity innate and provocative outbreaks, Naviaux and colleagues found a signal system in the body that is both linked to mitochondria and is important for innate immunity. They found it in nucleotide acid extracellular cells such as ATP (nucleotide organic compound in the living body, releasing energy when converted into another nucleotide, ADP) and other mitokines - a type of signaling molecule. created by old mitochondria.

These mitokines have separate metabolic functions outside of the cells that they bind to and they regulate receptors present on all cells of the body. Fifteen purine receptor muscle groups are stimulated by nucleotide extracellularity, and these receptors control a variety of biological characteristics that are associated with autism.

The researchers tested suramin mice - a purine signal inhibitor used in medicine to treat African sleeping sickness, soon after it was synthesized in 1916. They found that, This APT mediator can cure autism symptoms in laboratory animals, even when treatment is initiated after the symptoms of the disease have exploded. This drug restores 17 types of abnormal symptoms, including normalizing the structure of brain synapses, signaling between cells, social behavior, coordination of the motor nervous system and normalization. mitochondrial metabolism.

"The outstanding effect shown in this study is to use APT to 'reprogram' dangerous cell reactions and reduce mental agitation, opening up an opportunity to develop an antibiotic. to treat autism and some other disorders, " Naviaux said.

Zarazuela Zolkipli, Lin Wang, Tomohiro Nakayama, Jane C. Naviaux, Le Thuy P., Michael Schuchbauer, Mihael Rogac, Qingbo Tang, Laura L. Dugan, and Susan B. Powell are contributors to this research. .

Funding for the project is funded by Autism Speaks, UCSD Christini Foundation, Jane Botsford-Johnson Charity, Wright Family Charity Foundation, Lennox Charitable Foundation, Charitable Foundation Larry L. Hillblom, Gerber Charitable Foundation, and Hailey's Wish Foundation.

Autism is caused by abnormal communication between cells. Examining a new assumption, researchers at the University of California, San Diego School of Medicine used a newly discovered function of an old drug, to restore communication cells in a mouse. The sample has autism, which helps to reduce signs of dangerous mental disorders.