A drug for children can help treat cancer effectively

Scientists at UK's King's College London have discovered a way to combine chemotherapy with a drug for children that can support the immune system against cancer.

This result was published in the American Journal of Clinical Cancer Research on January 17.

According to the announcement, for the first time, scientists have tested the combination of chemotherapy with an internal drug, which helps activate the body's natural immune mechanism. This procedure affects the enzyme Heme Oxygenase-1 (HO-1), which works in some types of cancer. This enzyme can stimulate the growth of cubes by preventing the immune system from fighting cancer cells.

For the first time, scientists combined chemotherapy with a drug to treat jaundice in premature babies in the treatment of cancer.

Laboratory studies have shown that chemotherapy can stimulate the body's immune system to fight cancer cells. However, the team at King's College London found that this immune response is inhibited by macrophages that are lymphocytes that reside in the tumor and produce the HO-1 enzyme .

In pre-clinical studies, King's College London scientists have discovered a drug being tested in the treatment of jaundice in premature babies when combined with chemotherapy can prevent inhibition. above, thereby allowing the immune system to effectively attack cancer cells.

James Arnold, one of the team members, said the full effect of the treatment on patients will be clear once it is put into clinical treatment.

However, in preclinical trials, when combining the drug with chemotherapy, the tumor control effect is equivalent to that achieved in immunomodulatory therapy, which is expensive. Apply now.