Caspace-14 protects skin against UVB rays and dehydration

Ultraviolet rays can damage our skin and pave the way for skin cancer attacks.

The VIB scientists associated with Ghent University have demonstrated that the caspace-14 protein whose function has so far not been known not only plays a role in maintaining moisture balance but also shows protection against UVB rays. Future strategies to increase production of caspace-14 open up new possibilities to strengthen skin as a barrier against all types of inhibitors.

UV rays cause functional changes in the most important components of the skin: keratin . In addition, there is usually an extra cause of tanning and elimination of immune responses, UVB rays destroy DNA in the brain, which can lead to cancer.

Caspace is a protein that is involved in reactions that cause inflammation and cell death programmed or otherwise called apoptosis . In the mid-90s, Peter Vandenabeele and his colleagues isolated nine caspace divisions in rats. The properties and background of this caspace number are already known. However, caspace-14 is an unregulated ingredient , in which it is particularly found in the skin and is

Activated during the final stages of skin cell festering. Depending on the activity of caspace-14, the skin's outer epidermis contains dead cells and is released in the form of skin flakes.

To explore the function of caspace-14, Geertrui Denecker and colleagues, under the guidance of Wim Declercq and Peter Vandenabeele, experimented on anesthesia mice; It is impossible to produce protein anymore. The glossy skin and the bottle of mice without caspace-14 are signs of changing the texture of the skin epidermis. If lack of caspace-14 will cause drawbacks in the process of a protein, which plays a major role in maintaining skin structure and moisture balance. This can solve the dehydration of the skin, but one of the most important functions of the skin is to protect us against UVB radiation. Researchers at Ghent University found that the epidermal leaching action in mice without caspace-14 decreased significantly.

The absence of caspace-14 has a major detrimental effect on the function of protecting the skin, resulting in dehydration and reduced protection against UVB rays. This study sheds light on what mechanisms work in the skin's epidermis. The identification of molecular-dependent caspace-14 processes may be quite important in the pharmaceutical industry, always looking for agents to prevent tanning and skin aging.

Danh Phuong