Healing with umbilical cord blood

Umbilical cord blood transplantation for the treatment of malignant and hereditary blood is a new method currently being developed at the Hospital (BV) of Blood Transfusion and Hematology.

GS.BS. Tran Van Be and his colleagues at Ho Chi Minh City Blood and Blood Transfusion Hospital have spent many years researching this area, and have completed a large amount of valuable work so far.

Umbilical blood from newborns: Qualified quality

Treatment of umbilical cord blood in the laboratory in HCMC Blood and Hematology Hospital

He has succeeded in standardizing the umbilical cord blood collection techniques from newborns right after birth, handling umbilical cord blood to store frozen as well as after freezing before infusing to patients, screening Dialysis of antenatal mothers and postpartum umbilical cord blood on viral, bacterial infectious diseases .

This success is assessed by the scientific community as a turning point in the treatment of malignant and hereditary diseases in our country.

GS.BS. Tran Van Be said: The umbilical cord blood was taken on the umbilical vein of the placenta immediately after birth. The umbilical cord is first clamped to the end of the fetus with the fetus within 15 seconds of birth, umbilical cord umbilical cord and a syringe and needle to draw blood from the umbilical cord vein, then into the bag with anticoagulant solution, then Store with 10% DMSO solution at -196 degrees Celsius. This whole procedure must completely adhere to the sterile regime.

The umbilical cord blood unit must be checked after exclusion of infectious diseases such as viral hepatitis, syphilis, HIV, bacteria ., testing HLA, potential factors of congenital genetic disease.

The most difficult thing in this study is the treatment of cord blood that is grafted, especially in the process of decanting CD34 + cells (a valuable factor in the umbilical cord blood to help the human body be grafted with bone marrow. ). The satisfactory result is how to store umbilical cord blood frozen in liquid nitrogen and after the freezing of the number of cells is still not wasted.

The end result showed that CD34 + mononuclear cells have the same number as cord blood bank in Tokyo (Japan). Research in HCMC Blood Transfusion and Hematology Hospital showed that the rate of post-treatment cells reached 95.2% - a rate considered very high.

Umbilical cord blood transplant for patients: Successful .

Post-treatment hematopoietic stem cell products were grafted to 5 patients including 2 men and 3 women from 6 to 16 years of age with myeloid leukemia, leukemia and lymphoma and thalassemia. The product is grafted intravenously, depending on the MCR volume, which will last from 30 minutes to 4 hours.

The following patients grafted cord blood samples were produced in Ho Chi Minh City with the number of days of bone marrow growing similar to MCR samples imported from Tokyo bank.

In Ho Chi Minh City, the MCR bank has been established for several years, so far there have been more than 1,500 MCR samples that have properly processed and frozen standards, and in 2004 was recognized by the Asian MCR Association as MCR bank meets ASIA CORD standard. Since then Vietnam has become an official member of this International Association. Currently, MCR Ho Chi Minh City Bank has started participating in the tracing and exchange system with banks of Asian countries.

Big obstacle for transplanters: USD 30,000!

The main obstacle to the MCR transplant program in Vietnam is that the cost is very high compared to the average income of workers (about USD 30,000). In the future, if health insurance covers costs, many new patients will have access to this high-tech type.

People who give MCR must meet the criteria such as: mothers do not suffer from jaundice, hepatitis, nephritis, cardiovascular disease, congenital, congenital genetics, chronic diseases, infectious diseases.

The maximum blood pressure must be below 180 mmHg and the minimum is less than 100 mmHg, the circuit is 60-100 times / minute, the temperature is below 380C, the weight is over 40 kg. Children without deformities, do not suffer from congenital genetic diseases. At the same time, to avoid troubles later, the mother must make a written commitment not to complain and ask for anything after giving.

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