Preliminary assessment of the effects of Kacimex in the treatment of patients with benign benign hypertrophy at the Institute of Critical Disease Research and Treatment

QUESTION

- Prostate enlargement is a common disease in the elderly, affecting the health and operation of the elderly.
- Prostate enlargement due to many different causes, the disease accounts for a high proportion in common diseases in the elderly. According to Iaacs and Coffey 1989, in the US, the number of people suffering from LBP at age 40 is 25%, age 70 is 80%. In Vietnam, according to Tran Duc Tho et al. (1990) in the investigation of elderly health in Chu Phan commune, Me Linh district, Hanoi results showed that men over 50 years of age had morbidity rates of 59.18 %, age group from 75 - 79 infected to 76.92%.
- Health care for the elderly is an issue that is of special concern to countries in the world as well as in Vietnam.
- In the world as well as in Vietnam, the tendency to treat prostate enlargement is medical treatment to preserve but when medical treatment is not effective, surgical treatment (surgery) is removed. However, surgical treatments are not applicable to all patients and medical treatments often cause many side effects.
- We conducted research on KACIMEX medicine, a herbal-based, low-toxic, easy-to-use safe drug to treat and explore some cases of prostate hypertrophy.

Target:

• Preliminary assessment of the effects of KACIMEX in treating patients with prostate hypertrophy.
• Investigation of unwanted clinical side effects.

SUBJECTS AND METHODS OF RESEARCH

1. Standard
1.1.Standard selection of patients
- The patient must have an application for voluntary treatment and must cooperate with the physician
- Not suffering from acute and chronic diseases
- All patients diagnosed with prostate hypertrophy and have the following criteria:
Patients with incontinence disorders according to IPSS (International Prostaatic Symptoms Score)> 7
Prostatic prostate ultrasound, gland mass> 20 g
Urine volume remains
1.2.Standard type of patient
- Patients do not comply with treatment regulations.
- Patients suffering from acute and chronic diseases of the late stage.
- Patients with suspected cancer and other diseases related to prostate.

Medicine Kacimex.

2. Research drugs.
- Kacimex: Hard capsule 500mg, blister of 10 capsules .
The drug Kacimex has been tested independently for drugs including many different types of herbs, researched and produced by our Institute, based on the pharmacological features of each herb.
- Treatment dose:
Kacimex 500mg, 10 capsules daily divided 2 times x 3 months.

3. Research method:
Open method, comparing before treatment.

RESEARCH

Observation criteria:
- General health status: M, HA, Tº .
- Assessing the incidence of urinary disorders according to the IPSS scale (1991); *
- Volume and volume of prostate (ultrasound) **
- Residual urine volume (ultrasound)
- Unwanted side effects: allergies, rash, urticaria, fatigue, digestive disorders .

(*) IPSS scale:

Total score: 0 - 35
Based on the scale of points divided into 3 levels of incontinence disorder Mild disorder 0 - 7 points
The average disorder is from 8 to 19 points
Disorders weighing 20 to 35 points

(**) Calculate the volume according to Ellisoide's formula:
V = H x L x E x 0.523
Or by formula:
V = H x L x E / 2
V: Volume volume
H: Line height
L: Line width
L: Line thickness
Route volume: 1 cm³ of line organization is nearly 1g

Criteria for evaluating results:
Results are divided into 3 categories
- Type A:
+ The IPSS scale is mild
+ The volume of urine residues is reduced by more than 50% compared to before treatment
- Type B:
+ IPSS scale decreases a level
+ The volume of urine remaining in excess of 20% to 50% less than before treatment
- Type C:
+ The IPSS scale has little change
+ The volume of residual urine does not change or increase compared to before treatment

Patients were examined to monitor the results of prostate and clinical ultrasound before, during and after treatment (once a month for 3 months). After stopping treatment for 3 months, check prostate.

RESEARCH RESULTS

1. Characteristics of the research object
Eight patients with prostate gland.

Table 1. Classification of patients by age

Comment:
Age group 60-70 years of age, the highest rate of diseases accounted for 50%, as the study of the Geriatric Institute, the age group often suffered from fibroids mainly in the elderly (Over 60 years).

Table 2. Classification of patients according to the duration of disease.

Comment:
-The duration of the patient's discovery until the start of treatment is about 1-3 years, accounting for a majority of 50%.

Table 3. Classification of patients according to treated history without treatment

Comment:
The proportion of patients who have not received medical treatment once accounted for a high proportion of 62.5% and 37.5% of patients had medical treatment but did not help.

2. The clinical part
Table 4. Changes in clinical symptoms of patients before and after treatment

Comment:
Through Table 4, 100% of patients had urinary symptoms many times a day, at night, pee, small urine and dysuria.
After 1 month, the symptoms were significantly reduced, only 42.5% of patients still had urination many times a day and at night.
From the 2nd month symptoms symptoms above completely relieved and stable.

Table 5. Body weight results after 3 months of treatment

Comment:
After 3 months of treatment, 30% of weight gain patients> = 1 kg, so the drug works to restore patients' health, patients eat well, gain weight.

Table 6. Ultrasound results of patients before and after treatment (Prostate weight)

Comment:
The weight of prostate after 1 month of treatment is small compared to before treatment with P
Thus, the drug works to inhibit tumor growth and diminish the volume of the tumor.

III. Conclude
Preliminary results of treatment of 8 patients with prostate gland showed.
+ The drug has a good effect in treating prostate enlargement, clinical symptoms are relieved from the first month and continuously stabilize the following treatment period.
+ The drug has the ability to shrink fibroids, making prostate size return to normal physiological limits.
+ Medicines have the ability to recover health, patients eat well, sleep and gain weight.
Request
Need to treat a larger number of patients and replicate the effect of the drug on a scientific basis objectively.