Reserve fat cells like?

Researchers have found some genes in cells used to store fat. This finding offers a new perspective for weight loss therapy.

According to information released by US researchers in this week's issue of Proceedings Of The National Academy Of Sciences, these genes produce proteins that play a key role in fat storage.

Researcher David Silver and assistant professor of biochemistry at Albert Einstein University in New York City said: 'From this study we learned that if we could reduce the rate of these proteins in the cell, Cells will no longer have fat capacity. '

Mr. Silver explained that the gene 'fat accumulation is in the form of droplets to store energy later. Protein must participate in basic processes and be preserved throughout evolution '.

Finding the database, Silver and colleagues have identified two genes, named FIT1 and FIT2 , that appear in most of the original members of high-level cells that make up the human body called eukaryotes. . 'An ancient gene that has been around for a long time and then comes back to life in enamel'.

(Artwork: Dellonutritionals.com) Other scientists have just discovered that these two genes are responsible for the synthesis of fat in cells . They combine fat into droplets within a class of phosphplipid and protein molecules. Both genes produce proteins made up of more than 200 units of units called amino acids. These two genes are similar to 50%. According to the researchers, the amino acid sequence found in the FIT gene is not the same as the protein structure of any species.

Silver said there were a series of experiments that confirmed the role of the FIT gene in fat accumulation.
In one experiment, a copy of the gene was inserted into human cells. The rate of fat synthesis in these cells did not change, but the amount of fat produced increased by 4-6 times.

Another experiment reduced the activity of a FIT gene in mouse fat cells. This reduces the amount of fat produced in those cells.

The researchers injected the inhibitors of the two genes into zebrafish experiments. The fish is provided with a high-fat diet for 6 hours, but their liver and intestinal tests do not show signs of fat.

Silver said the mice without the two genes are being studied to find out what happens to animals that can't synthesize fats. The question is: ' Where does fat go when the body can't store it? ' ' There are two possibilities. One is that the body will react positively and burn fat. The second possibility of potential toxins when fat exists somewhere. '

By discovering these two genes, we can study drugs that change their activity - both beneficial in treating obesity and working with diseases like diabetes and heart attack.

'We can set up a very basic process and based on which all organisms can store fat. It is a fairly primitive discovery '.

Dawn Brasaemle, associate professor of nutritional science at Rutgers University, who has studied lipid droplets since they first became known in the 1990s, commented on the study as ' a discovery. have a profound effect '. This field is so new that the first scientific discussion meeting about it was held only last summer.

According to Ms Brasaemle, Silver's first obstacle was to understand how these two genes work together with other genes in fat synthesis. She added: 'Then we have to understand how important they are to health. Is there any way to combine their activity with drugs? Can they become targets for drug intervention to prevent fat accumulation? We have only achieved the first steps in research on these two genes. '