Symptoms, complications of gout and medication treatment

Gout is characterized by elevated levels of uric acid in the blood leading to deposition of local monosodium urate (MSU) crystals in tissues or joints.

Some symptoms, complications of gout and medication treatment

The direct factor that causes disease is MSU crystals , not uric acid dissolved in the blood, so high blood uric acid does not necessarily mean gout. Gout is manifested by acute swollen joints besides the chronic MSU crystal deposition in tissues especially kidneys.

The diagnosis usually applies Bennett Wood 1968 diagnostic criteria, but due to the abuse of treatment drugs that cause symptoms of the disease and the appearance of additional side effects of the drug makes the diagnosis more difficult. .

Treatment of diseases includes lifestyle changes and anti-inflammatory, analgesic, and reduced uric acid levels . The more anti-inflammatory anti-inflammatory drugs are used early in the course of symptoms, the faster the seizure effect is. Complications of gout include disease-related complications and treatment-related complications.

Symptoms and complications related to the disease

Particle tophi:

1. This is a manifestation of chronic gout, which affects aesthetics, reduces social communication confidence, and reduces joint function.
2. Tophi is difficult to detect : access pathway of bacteria causes joint infection, if on the background of immunocompromised patients due to corticosteroids, it is very easy for sepsis.

Kidney complications :

1. Urat stones of the kidney : are unstoppable stones, can only detect through urinary ultrasound system
2. Interstitial nephritis, pyelonephritis, urinary tract infection due to pus retention due to urat stones
3. Chronic kidney failure: reduces uric acid waste, increases the risk of acute gout attacks, and difficulty in taking anti-inflammatory drugs.
4. Shallow phlebitis of the lower extremities: need treatment with colchicine. Common in patients with associated metabolic syndrome: hypertension, hyperglycemia, dyslipidemia, heart fat .

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Complications related to treatment of disease

1. Complications due to anti-inflammatory analgesic : peptic ulcer, small intestine. Increased in patients with coronary artery disease. Increased renal failure. Increased risk of infection.
2. Complications due to colchicine use: acute diarrhea, especially when overdose.
3. Complications due to drug allergies (such as allopurinol, antibiotics .): patients with gout often have a very susceptible to allergies, even patients allergic to all medications for gout.

Complications due to corticoid use:

1. This is a big burden, this group of drugs is cheap, easy to buy, quick to relieve pain, so it is often abused. . sell at high prices. Patients who drink good pain think that it is expensive, the next time they drink again. This group drug reduces uric acid waste through the kidneys, causing acid to build up into tophi particles, the disease becomes chronic.
2. A variety of other side effects of corticosteroids : increased risk of osteoporosis, hypertension, diabetes, cataracts, gastrointestinal bleeding, adrenal insufficiency .

Being a smart patient, when sick, go to prestigious medical facilities to provide counseling and treatment to avoid losing money